PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
Decomposes
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
GENERAL DESCRIPTION & APPLICATIONS
Semicarbazide is an urea derivative in which one amide group of urea is replaced by hydrazine residue. The formula is H2NNHC(=O)NH2. The hydrochloride salt of semicarbazide is a white crystal; melting point 175 C; very soluble in water. It is used in preparing pharmaceuticals including nitrofuran antibacterials (furazolidone, nitrofurazone, nitrofurantoin) and related compounds. It is used as a derivatization reagent for aldehydes and ketones. It produces crystalline compounds with characteristic melting points with aldehydes and ketones and thus used as a derivation reagent. It is used as a solvent to separate hormones and essential oils. Semicarbazone is a ketone form of semicarbazide which is derived by the condensation reaction between a ketone (or aldehyde) and a semicarbazide, R2C=NNHC(=O)NH2. Thiosemicarbazone contains a sulfur atom in stead of oxygen in the ketone. Semicarbazone products Both semicarbazones and thiosemicarbazones are known to have an activity of antiviral, antiinfective and antineoplastic through binding to copper or iron in cells. Some examples are:
|
Product |
Activity |
CAS RN. |
| Nitrofurazone | anti-infective agent, Trypanocidal agent | 59-87-0 |
| Carbazochrome | Hemostatics | 69-81-8 |
| Carbazochrome sodium sulfonate |
|
51460-26-5 |
| Subathizone | Antitubercular agent | 121-55-1 |
| Nidroxyzone | Chemotherapeutic | 405-22-1 |
| Ambazone | Antineoplastic agent, Bacteriostatic | 539-21-9 |
| Nicothiazone | Tuberculostatic | 555-90-8 |
| Methisazone | Antiviral agent | 1910-68-5 |
| Naftazone |
|
15687-37-3 |
| Gloxazone | Veterinary Anaplasmodastat, Antineoplastic agent, Antiprotozoal agent | 2507-91-7 |
| Nifursemizone | Antiprotozoal | 5579-89-5 |
| Nifurethazone |
|
5580-25-6 |
| Ambazone |
Antiseptic |
6011-12-7 |
| Iprazochrome | Serotonin antagonist | 7248-21-7 |
| Bitipazone |
|
13456-08-1 |
| Citenazone | Antiviral agent | 21512-15-2 |
| Pimagedine | Enzyme inhibitor | 79-17-4 |
| Phenicarbazide | Fungicide, bactericide | 103-03-7 |
| Dichlofluanid | Fungicide, bactericide | 1085-98-9 |
| Tolazamide | Antidiabetic, Hypoglycemic agent | 1156-19-0 |
| Goserelin | Hormonal antineoplastic agent | 65807-02-5 |
| Ramorelix | Hormone antagonist | 127932-90-5 |
APPEARANCE
PURITY
99.0% min
173 - 177 C
SULFATED ASH
0.02% max
INSOLUBLES
0.02% max (in water)